Structural and Functional Analysis of Human Proteasome Complexes

The proteasome is the proteolytic machinery of the ubiquitin-proteasome system (UPS), the main pathway responsible for degradation of intracellular proteins. As the major cellular protease, the proteasome is a key player in eukaryotic protein homeostasis and dysregulation of the UPS has been involved in neurodegenerative diseases and cancers. Because of this, protea­somes have been identified as therapeutic targets, especially for some cancers. Therefore, understanding the structure/function relationship controlling proteasome activity is of major interest in biology.